The distinct roles of monoamines in multiple sclerosis: A bridge between the immune and nervous systems?

The monoaminergic neurotransmitters dopamine, noradrenaline, and serotonin are pivotal actors of the interplay between nervous immune system due to their ability binding cell-receptors both systems, crucially regulating function within central periphery. As monoamines dysfunctional in many neurological psychiatric diseases, they have been successfully used as pharmacological targets. Multiple sclerosis (MS) is one best examples disease caused by an altered interaction emerging evidence supports a dysregulation systems pathogenesis MS, secondary inflammation-induced reduction monoamines’ synthesis structural damage pathways brain. Here we review for being key mediators neuroimmune interaction, affecting MS course. Moreover, discuss how reduction/dysfunction may contribute some clinical features typical disease, particularly fatigue depression. Finally, summarize different drugs targeting that currently under evaluation potential efficacy treat well alleviate depression MS.